Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies

Background The association of atopic dermatitis (AD) and allergic contact has been a matter considerable uncertainty. Study results range from lack any to increased sensitization for multiple allergens, but fail identify consistent allergen associations. Objective We studied large patch test cohort patients stratified by their skin diathesis using the Erlangen Atopy Score (EAS), independent active disease. Methods Retrospective multi-center data analysis five departments dermatology in Germany with 4,509 patients. Patients were grouped as “no diathesis” (n = 2,165) “atopic 1,743), according EAS. Results Significantly more individuals showed at least one positive reaction baseline series compared without (49.1 % vs. 38.3 %). In logistic regression analyses, was associated significantly higher risk methylchloroisothiazolinone/methylisothiazolinone (OR 2.383) methylisothiazolinone 1.891), thiuram mix 1.614), well nickel 1.530), cobalt 1.683), chromium 2.089). Conclusions Atopic proved be most important intrinsic factor few, specific allergens. Past or present AD less relevant variable.